Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia , exaggeration of pain, and punctuate hyperalgesia , extreme sensitivity to pain. Two types of mechanical hyperalgesia can occur: 1) touch that is normally painless in the uninjured surroundings of a cut or tear can trigger painful sensations (touch-evoked hyperalgesia), and 2) a slightly painful pin prick stimulation is perceived as more painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require continuous firing which means it can persist for hours after a trauma and can be stronger than normally experienced. In addition, it was found that patients with neuropathic pain, histamine ionophoresis resulted in a sensation of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spinal hypersensitivity to C-fiber input in chronic pain. 
I pin 2 iu daily the first week and could feel something but chalked it up to placebo. Bumped it to 3iu on MWF and 4 on Tuesday/Thursday and that when typical sides kicked in. My hands are already weighing me down but now they are like bricks sometimes. I have slight carpel, but the good outweighs the bad. Skin has improved hair no longer being considered a total loss, nails look prime for biting, and my favorite, the sleep. My sleep is great. Taking addiction meds makes difficult to fall asleep, but that hasn't been case since week 3. I'm in my 6th week now and feel great as the fat starts to come off for my transformation. For GH I am mainly concerned with overall well being than fat loss. I may lower the Tues/Thursday dose to 3iu. I've taken Humatrope throughout my usage, and while this isnt exactly equal, for the money it's my new go to.