We identified 19 eligible studies (3459 individuals), all observational; 13 studies (1917 individuals) were suitable for inclusion in the meta-analysis of mortality . Of these, 12 studied patients infected with 2009 influenza A H1N1 virus (H1N1pdm09). Risk of bias was greatest in the 'comparability domain' of the Newcastle-Ottawa scale, consistent with potential confounding by indication. Data specific to mortality were of very low quality. Reported doses of corticosteroids used were high and indications for their use were not well reported. On meta-analysis , corticosteroid therapy was associated with increased mortality ( odds ratio ( OR ) , 95% confidence interval ( CI ) to ). Pooled subgroup analysis of adjusted estimates of mortality from four studies found a similar association ( OR , 95% CI to ). Three studies reported greater odds of hospital-acquired infection related to corticosteroid therapy ; all were unadjusted estimates and we graded the data as very low quality.
When first administering steroids, a man will have an increase in sexual function. This unfortunately is only temporary as your body becomes used to the steroid in its system. With prolonged use of a steroid, eventually, the man will feel less sexual desire, and will be less capable of maintaining an erection. Luckily, this is only temporary as well and can even be totally prevented with the use of substance such as Gonakor and HCG. Also when the steroid use is discontinued, the body’s natural level of testosterone (like the immune system) will certainly be suppressed.