Some of the approved drugs are synthetic versions of the natural hormones, such as trenbolone acetate and zeranol. Just like the natural hormone implants, before FDA approved these drugs, FDA required information and/or toxicological testing in laboratory animals to determine safe levels in the animal products that we eat (edible tissues). Furthermore, FDA required that the manufacturers demonstrate that the amount of hormone left in each edible tissue after treatment is below the appropriate safe level. As described above, a safe level is a level which would be expected to have no harmful effect in humans.
The genetic basis of four forms of severe hypertension transmitted on an autosomal basis has also been determined. All of these conditions are characterized by salt-sensitive increases in blood pressure, indicating an increased mineralocorticoid effect. The four disorders—aldosteronism, mineralocorticoid excess syndrome, activating mutation of the mineralocorticoid receptor, and Liddle syndrome—are a consequence of either abnormal biosynthesis, abnormal metabolism, or abnormal action of steroid hormones and the development of hypertension. Adrenal insufficiency is known as Addison’s disease and causes death within two weeks unless treated. Classical Addison’s disease results from a loss of both cortisol and aldosterone secretion as a result of the near total or total destruction of both adrenal glands.