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09/11/2010 06:11:18 PM(main): DwgConnectConnection : constructor :
ConnectConnection: jdbc:oracle:thin:@localhost:1522:XE snpw1 INTERNAL_WORK_3317565
Forty three eligible trials (48 comparisons) were identified. These included 9742 women, 55% of whom were receiving first-line treatment for metastatic disease. For overall survival there was a statistically significant difference in favour of the combination regimens with no heterogeneity (HR , 95% CI -, p<). Results were very similar when trials of first-line treatment were analysed, and for analyses where the single agent was also included in the combination regimen . Combination regimens showed a statistically significant advantage for survival over single agent taxane (HR ; 95% CI -, p<), but not anthracycline (HR -, p=).