These eye drops and ointments contain a combination of a steroid and one or more types of antibiotic for treatment of infection and inflammation of the eye. The steroid reduces inflammation while the antibiotic treats or prevents infection which may be the cause of the infection. Examples of steroids that are used in these eye drops are hydrocortisone, loteprednol, prednisolone, and dexamethasone . Examples of antibiotics used in these formulations include tobramycin, neomycin, bacitracin, polymixin B, and gentamycin. These antibiotics have different mechanisms of action and two or three may be combined in one formulation.
An excessive level of corticosteroids may cause Cushing's disease. When a pet is on long-term, high doses of glucocorticoids, there is an increased risk that it will develop a condition called iatrogenic (medication induced) Cushing's disease. The clinical signs of Cushing's disease include increased thirst and urination, an increase in UTI's and skin and ear infections, a "pot-bellied" appearance, thinning skin and hair loss. In the treatment of some diseases, the risk of iatrogenic Cushing's disease is unavoidable. To minimize this risk, corticosteroid doses are tapered down over time, or several different drugs may be used in combination.
Last year I developed a rash under my eyes and I was promptly prescribed hydrocortisone cream. It didn't help much and the doctor referred me to see a dermatologist. I was told to keep using the hydrocortisone and I was discharged. As the steroid cream didn't help I searched the internet for another remedy and that's how I came across a product called Magicream. It claims it only contains natural ingredients and it promised to clear up my rash. I was so excited! I have recently found out that the cream in fact contains Clobetasol Propionate and Ketoconazole. I was devastated to find this out especially since side effects include red spots and a burning sensation! When I stopped using the cream the side effects were terrible - I don't need to tell you as you know how the withdrawal of steroid can affect ones face. I then did a search on line and found your website which made so much sense and helped me to understand what was happening with my skin. I ordered the Face & Body Wash and the Face & Neck TheraCream and I have been symptom FREE ever since. Thank you from a once frustrated person!! Trish Managold, UK