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The new Warning will alert prescribers to the abuse potential of testosterone and the serious adverse outcomes, especially those related to heart and mental health that have been reported in association with testosterone/AAS abuse. In addition to the new Warning, all testosterone labeling has been revised to include information in the Abuse and Dependence section about adverse outcomes reported in association with abuse and dependence of testosterone/AAS, and information in the Warning and Precautions section advising prescribers of the importance of measuring serum testosterone concentration if abuse is suspected. Prescription testosterone products are FDA-approved as hormone replacement therapy for men who have low testosterone due to certain medical conditions. Examples of these conditions include failure of the testicles to produce testosterone because of genetic problems, or damage to the testicles from chemotherapy or infection.
The legal status of anabolic steroids varies from country to country. In the ., anabolic steroids are listed as Schedule III controlled substances under the Controlled Substances Act , which makes the possession of such substances without a prescription a federal crime punishable by up to seven years in prison.  In Canada, anabolic steroids and their derivatives are part of the Controlled drugs and substances act and are Schedule IV substances, meaning that it is illegal to obtain or sell them without a prescription. However, possession is not punishable, a consequence reserved for schedule I, II or III substances. Those guilty of buying or selling anabolic steroids in Canada can be imprisoned for up to 18 months. Importing or exporting anabolic steroids also carry similar penalties.  Anabolic steroids are also illegal without prescription in Australia,  Argentina, Brazil, and Portugal,  and are listed as Schedule 4 Controlled Drugs in the United Kingdom.