Approach to lymphocytosis: ALC>4000/uL
It's either reactive or clonal:
- viral: HIV (in acute infection), EBV (mono), CMV, HHV6, HTLV-1
- bac: bordatella pertussis, bartonella (cat scratch disease)
- toxo, babesiosis (also causes hemolytic anemia)
2) Hypersensitivity reactions
- drugs, acute serum sickness
3) stress-induced (status epilepticus, trauma)
4) post splenectomy
5) polyclonal B cell lymphocytosis
3) LGL leukemia
Thomas M Wheeler, MD Chairman, Department of Pathology and Immunology, WL Moody, Jr, Professor of Pathology, Professor of Urology, Baylor College of Medicine
Thomas M Wheeler, MD is a member of the following medical societies: Alpha Omega Alpha , American Association for Cancer Research , American Medical Association , American Society for Clinical Pathology , American Society of Cytopathology , American Thyroid Association , American Urological Association , College of American Pathologists , United States and Canadian Academy of Pathology , International Society of Urological Pathology , Harris County Medical Society
Disclosure: Received stock from PathXL for medical advisory board. for: PathXL, Inc.
Women of childbearing age tend to have lower hematocrit levels than men due to loss of iron and blood during menstrual periods and increased need for iron during pregnancy . People who have a chronic illness such as kidney disease , cancer, HIV/AIDS , chronic infection or autoimmune disorder (., rheumatoid arthritis ) are at risk for abnormally low hematocrit. Others who are at greater risk of a low hematocrit ( anemia ) include people with poor nutrition and diets low in iron or vitamins, people who have undergone surgery or people who have been severely injured. Someone who has family members with a genetic cause of anemia such as sickle cell or thalassemia also have a higher risk of having the condition and a higher risk of anemia.