Various adverse drug reactions have been reported in association with the use of XANAX since market introduction. The majority of these reactions were reported through the medical event voluntary reporting system. Because of the spontaneous nature of the reporting of medical events and the lack of controls, a causal relationship to the use of XANAX cannot be readily determined. Reported events include: gastrointestinal disorder, hypomania , mania , liver enzyme elevations, hepatitis , hepatic failure, Stevens-Johnson syndrome , photosensitivity reaction, angioedema , peripheral edema, hyperprolactinemia, gynecomastia , and galactorrhea (see PRECAUTIONS ).
Alprazolam may be quantified in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest, or to assist in a medicolegal death investigation. Blood or plasma alprazolam concentrations are usually in a range of 10–100 μg/L in persons receiving the drug therapeutically, 100–300 μg/L in those arrested for impaired driving, and 300–2000 μg/L in victims of acute overdosage. Most commercial immunoassays for the benzodiazepine class of drugs cross-react with alprazolam, but confirmation and quantitation is usually performed using chromatographic techniques.   
Cocaine use and abuse continues to be a growing problem in the United States and is considered to be one of the most abused stimulants in America. Recently, cocaine has been named as the drug most often involved in visits to the emergency room. It’s estimated that million people use cocaine each month – 359,000 of those used crack cocaine. More men than women abuse cocaine each month. Adults between the ages of 18 and 25 report higher rates of cocaine usage with % of individuals in this age bracket self-reporting cocaine abuse in the past month. Cocaine has been and continues to be a growing drug problem in the United States.